Amyloidosis

Posted by e-Medical PPT Wednesday, September 29, 2010
Amyloidosis refers to a variety of conditions in which amyloid proteins are abnormally deposited in organs and/or tissues. A protein is described as being amyloid if, due to an alteration in its secondary structure, it takes on a particular aggregated insoluble form similar to the beta-pleated sheet.Symptoms vary widely depending upon the site of amyloid deposition. Amyloidosis may be inherited or acquired.
More common types of amyloid are,
Amyloid light chain - Contains immunoglobulin light-chains (λ,κ) derived from plasma cells.It is found in multiple myeloma
β amyloid -Found in Alzheimer disease brain lesions
Amylin - Found in the pancreas of patients with type 2 diabetes
Prion protein - In prion diseases, misfolded prion proteins deposit in tissues and resemble amyloid proteins. Some examples are Creutzfeldt–Jakob disease (humans), "mad cow disease" (cattle), and scrapie (sheep and goats).

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